Taking the blood gives you a useful supply of Blood Vials, while destroying it means leaving those extra supplies behind.
If you choose to take some, Coen still gets rid of most of the blood in the cellar. The main difference is that he keeps some of it for himself.
So if you’re mainly thinking about immediate gameplay value, taking the blood is useful.
What Happens If You Take the Blood?
Coen keeps some of the stored blood instead of destroying all of it.
This gives you Blood Vials, which can be useful when you need another source of blood later.
You are not simply leaving Ambrus’ entire blood supply untouched—the rest is still dealt with as part of clearing the cellar.
What Happens If You Destroy the Blood?
Choosing to destroy it means you don’t take the extra Blood Vials for yourself.
This is the cleaner choice if you don’t want Coen benefiting from blood that Ambrus’ operation collected from other people.
From a practical gameplay perspective, though, you are giving up supplies that could have been useful later.
Is Taking the Blood Better?
For the immediate reward, yes.
Taking some gives you something useful to carry with you, while destroying everything does not give you that same benefit.
That makes Take an attractive option if you’re short on blood or simply want more supplies before continuing.
Does Taking the Blood Have Consequences Later?
That part isn’t fully clear yet.
The game has only just launched, and there is not enough confirmed information yet to say that taking the blood changes a later quest, ending, or other major story outcome.
So far, the clear difference is the Blood Vials you receive by taking it.
Until the longer-term consequence is properly confirmed, it is better not to assume that either choice is completely consequence-free.
Quick Answer
Take the blood if you want the extra Blood Vials. Destroy it if you would rather refuse to use Ambrus’ stolen blood.
Taking some of the blood does not mean leaving the whole cellar intact—you still deal with the rest while keeping a small amount for yourself.
For now, the Blood Vials are the clear gameplay difference between the two choices. Any larger long-term consequence is still being documented.
